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Article

Molecular determinants of species-specific activation or blockade of TRPA1 channels.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 May 2008

Chen Jun, Zhang Xu-Feng, Kort Michael E, Huth Jeffrey R, Sun Chaohong, Miesbauer Laura J, Cassar Steven C, Neelands Torben, Scott Victoria E, Moreland Robert B, Reilly Regina M, Hajduk Philip J, Kym Philip R, Hutchins Charles W, Faltynek Connie R

Abstract excerpt

TRPA1 is an excitatory, nonselective cation channel implicated in somatosensory function, pain, and neurogenic inflammation. Through covalent modification of cysteine and lysine residues, TRPA1 can be activated by electrophilic compounds, including active ingredients of pungent natural products (...

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Identifiers

PMID: 18463259
DOI: 10.1523/JNEUROSCI.0047-08.2008
PMCID: PMC6670736

Genes

TRPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18463259-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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