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Article

Benzoquinone reveals a cysteine-dependent desensitization mechanism of TRPA1.

Molecular pharmacology - 1 May 2013

Ibarra Yessenia, Blair Nathaniel T

Abstract excerpt

The transient receptor potential ankyrin 1 (TRPA1) nonselective cation channel has a conserved function as a noxious chemical sensor throughout much of Metazoa. Electrophilic chemicals activate both insect and vertebrate TRPA1 via covalent modification of cysteine residues in the amino-terminal region. Although naturally occurring electrophilic plant compounds, such as mustard oil and cinnamaldehyde, are TRPA1...

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Identifiers

PMID: 23478802
DOI: 10.1124/mol.112.084194
PMCID: PMC3629832

Genes

TRPA1

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Related research

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