Article

A novel TRPA1 gain-of-function variant associated with painful sensory neuropathy acts through a PIP2 gating mechanism.

2026-08-13

Abstract excerpt

TRPA1 (transient receptor potential ankyrin 1) is a non-selective, calcium-permeable cation channel that mediates pain by detecting environmental irritants and thermal stimuli. Although the role of TRPA1 in modulating pain perception is relatively well established, so far only a few human TRPA1 variants (N855S and A172V) have been associated with inherited neuropathic pain disorders. Here, we describe a novel TRPA...

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Literature Corpus work: 443fb787-b0ad-5f9a-ac11-7af7922d46f2
DOI: 10.64898/2026.08.13.744390

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