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Article

The structural basis of R-spondin recognition by LGR5 and RNF43.

Genes & development - 15 Jun 2013

Chen Po-Han, Chen Xiaoyan, Lin Zhenghong, Fang Deyu, He Xiaolin

Abstract excerpt

R-spondins (RSPOs) enhance Wnt signaling, affect stem cell behavior, bind to leucine-rich repeat-containing G-protein-coupled receptors 4-6, (LGR4-6) and the transmembrane E3 ubiquitin ligases RING finger 43/zinc and RING finger 3 (RNF43/ZNRF3). The structure of RSPO1 bound to both LGR5 and RNF43 ectodomains confirms their physical linkage. RSPO1 is sandwiched by LGR5 and RNF43, with its rod module of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23756651
DOI: 10.1101/gad.219915.113
PMCID: PMC3701190

Genes

RNF43
RSPO1
ZNRF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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