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Article

Kinetics of the CTLA-4 isoforms expression after T-lymphocyte activation and role of the promoter polymorphisms on CTLA-4 gene transcription.

Human immunology - 1 Sept 2013

Pérez-García Arianne, Osca Gemma, Bosch-Vizcaya Anna, Kelleher Nichollas, Santos Nazly Y, Rodríguez Rocío, González Yolanda, Roncero Josep M, Coll Rosa, Serrando Maite, Lloveras Natàlia, Tuset Esperanza, Gallardo David

Abstract excerpt

Cytotoxic T lymphocyte antigen 4 (CTLA-4) plays a key inhibitory role during T lymphocyte activation. The CTLA4 gene is translated into two proteic isoforms: a full-length protein (flCTLA-4) and a soluble counterpart. We explored the expression of both isoforms on healthy subjects. Whereas in non-stimulated cells the flCTLA-4 isoform is predominant, after stimulation the expression of the soluble form rapidly...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23756164
DOI: 10.1016/j.humimm.2013.05.012

Genes

CTLA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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