Overexpression and secretion of the soluble CTLA-4 splice variant in various autoimmune diseases and in cases with overlapping autoimmunity.

doi:10.1089/gtmb.2012.0391

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Article

Overexpression and secretion of the soluble CTLA-4 splice variant in various autoimmune diseases and in cases with overlapping autoimmunity.

Genetic testing and molecular biomarkers - 1 Apr 2013

AlFadhli Suad

Abstract excerpt

AIM: To explore the potential genetic association of CTLA-4 Exon1 +49A/G and 3'UTR (AT)(n) to susceptibility to systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and overlapping (OP) autoimmunity; affected with more than one autoimmune disease. Expression of two major CTLA-4 isoforms; full length (mCTLA-4) and soluble (sCTLA-4) were explored in all subjects. A total of 680-age/gender/ethnically...

Topics

3' Untranslated Regions
Adult
Aged
Arthritis, Rheumatoid
Autoimmune Diseases
Autoimmunity
CTLA-4 Antigen
Exons
Female
Genetic Predisposition to Disease
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Heterozygote

Humans

Kuwait

Lupus Erythematosus, Systemic

Male

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 23448385
DOI: 10.1089/gtmb.2012.0391
PMCID: PMC3609615

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