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Article

The soluble CTLA-4 receptor and its role in autoimmune diseases: an update

1 Nov 2010

Abstract excerpt

CTLA-4, initially described as a membranebound molecule, is a costimulatory receptor transducing a potent inhibitory signal. Increasing evidence shows the CTLA-4 gene to be an important susceptibility locus for autoimmune endocrinopathies and other autoimmune disorders. A soluble form of cytotoxic T-lymphocyte-associated antigen-4 (sCTLA-4) has been established and shown to possess CD80/CD86 binding activity and...

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PMID: 26000110
DOI: 10.1007/s13317-010-0011-7

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