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Article

Ctla-4 expression and polymorphisms in lung tissue of patients with diagnosed non-small-cell lung cancer.

BioMed research international - 1 Jan 2013

Antczak Adam, Pastuszak-Lewandoska Dorota, Górski Paweł, Domańska Daria, Migdalska-Sęk Monika, Czarnecka Karolina, Nawrot Ewa, Kordiak Jacek, Brzeziańska Ewa

Abstract excerpt

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is a potent immunoregulatory molecule that downregulates T-cell activation and thus influences the antitumor immune response. CTLA-4 polymorphisms are associated with various cancers, and CTLA-4 mRNA/protein increased expression is found in several tumor types. However, most of the studies are based on peripheral blood mononuclear cells, and much less is known...

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Identifiers

PMID: 23936819
DOI: 10.1155/2013/576486
PMCID: PMC3722891

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Source receipt: pubmed, retrieved 7 Sept 2026.

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