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Article

In silico screening, genotyping, molecular dynamics simulation and activity studies of SNPs in pyruvate kinase M2.

PloS one - 1 Jan 2015

Kalaiarasan Ponnusamy, Kumar Bhupender, Chopra Rupali, Gupta Vibhor, Subbarao Naidu, Bamezai Rameshwar N K

Abstract excerpt

Role of, 29-non-synonymous, 15-intronic, 3-close to UTR, single nucleotide polymorphisms (SNPs) and 2 mutations of Human Pyruvate Kinase (PK) M2 were investigated by in-silico and in-vitro functional studies. Prediction of deleterious substitutions based on sequence homology and structure based s...

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Identifiers

PMID: 25768091
DOI: 10.1371/journal.pone.0120469
PMCID: PMC4359060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25768091-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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