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Article

The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme.

PloS one - 1 Jan 2018

Fiorillo Annarita, Petrosino Maria, Ilari Andrea, Pasquo Alessandra, Cipollone Alessandra, Maggi Maristella, Chiaraluce Roberta, Consalvi Valerio

Abstract excerpt

Cancer cells are able to survive in difficult conditions, reprogramming their metabolism according to their requirements. Under hypoxic conditions they shift from oxidative phosphorylation to aerobic glycolysis, a behavior known as Warburg effect. In the last years, glycolytic enzymes have been identified as potential targets for alternative anticancer therapies. Recently, phosphoglycerate kinase 1 (PGK1), an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29995887
DOI: 10.1371/journal.pone.0199191
PMCID: PMC6040698

Genes

PGK1

Provenance

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