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Article

Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A.

PloS one - 1 Jan 2014

Price Jessica C, Pollock Lana M, Rudd Meghan L, Fogoros Sarah K, Mohamed Hassan, Hanigan Christin L, Le Gallo Matthieu, Zhang Suiyuan, Cruz Pedro, Cherukuri Praveen F, Hansen Nancy F, McManus Kirk J, Godwin Andrew K, Sgroi Dennis C, Mullikin James C, Merino Maria J, Hieter Philip, Bell Daphne W

Abstract excerpt

Most endometrial cancers can be classified histologically as endometrioid, serous, or clear cell. Non-endometrioid endometrial cancers (NEECs; serous and clear cell) are the most clinically aggressive of the three major histotypes and are characterized by aneuploidy, a feature of chromosome instability. The genetic alterations that underlie chromosome instability in endometrial cancer are poorly understood. In...

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Source

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Identifiers

PMID: 23755103
DOI: 10.1371/journal.pone.0063313
PMCID: PMC3670891

Genes

CHTF18
ESCO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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