Article
Somatic mutation profiles of clear cell endometrial tumors revealed by whole exome and targeted gene sequencing.
Cancer - 1 Sept 2017
Le Gallo Matthieu, Rudd Meghan L, Urick Mary Ellen, Hansen Nancy F, Zhang Suiyuan, Lozy Fred, Sgroi Dennis C, Vidal Bel August, Matias-Guiu Xavier, Broaddus Russell R, Lu Karen H, Levine Douglas A, Mutch David G, Goodfellow Paul J, Salvesen Helga B, Mullikin James C, Bell Daphne W
Abstract excerpt
BACKGROUND: The molecular pathogenesis of clear cell endometrial cancer (CCEC), a tumor type with a relatively unfavorable prognosis, is not well defined. We searched exome-wide for novel somatically mutated genes in CCEC and assessed the mutational spectrum of known and candidate driver genes in a large cohort of cases. METHODS: We conducted whole exome sequencing of paired tumor-normal DNAs from 16 cases of...
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