Article
Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition.
Human genetics - 1 Mar 2015
Moir-Meyer Gemma L, Pearson John F, Lose Felicity, Scott Rodney J, McEvoy Mark, Attia John, Holliday Elizabeth G, Pharoah Paul D, Dunning Alison M, Thompson Deborah J, Easton Douglas F, Spurdle Amanda B, Walker Logan C
Abstract excerpt
Endometrial cancer is the most common invasive gynaecological cancer in women, and relatively little is known about inherited risk factors for this disease. This is the first genome-wide study to explore the role of common and rare germline copy number variants (CNVs) in predisposition to endometrial cancer. CNVs were called from germline DNA of 1,209 endometrioid endometrial cancer cases and 528...
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