Article
Patterns of CTCF and ZFHX3 Mutation and Associated Outcomes in Endometrial Cancer.
Journal of the National Cancer Institute - 1 Nov 2015
Walker Christopher J, Miranda Mario A, O'Hern Matthew J, McElroy Joseph P, Coombes Kevin R, Bundschuh Ralf, Cohn David E, Mutch David G, Goodfellow Paul J
Abstract excerpt
BACKGROUND: The genetic events responsible for tumor aggressiveness in endometrioid endometrial cancer (EEC) remain poorly understood. The chromosome 16q22 tumor suppressor genes CTCF and ZFHX3 are both frequently mutated in EEC, but their respective roles in outcome have not been determined. METHODS: Targeted deep sequencing of CTCF and ZFHX3 was performed for 542 EEC samples. Copy number loss (CNL) was...
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