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Article

The genetic code constrains yet facilitates Darwinian evolution.

Nucleic acids research - 1 Aug 2013

Firnberg Elad, Ostermeier Marc

Abstract excerpt

An important goal of evolutionary biology is to understand the constraints that shape the dynamics and outcomes of evolution. Here, we address the extent to which the structure of the standard genetic code constrains evolution by analyzing adaptive mutations of the antibiotic resistance gene TEM-1 β-lactamase and the fitness distribution of codon substitutions in two influenza hemagglutinin inhibitor genes. We...

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Identifiers

PMID: 23754851
DOI: 10.1093/nar/gkt536
PMCID: PMC3753648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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