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Article

The Standard Genetic Code Facilitates Exploration of the Space of Functional Nucleotide Sequences.

Journal of molecular evolution - 1 Jul 2018

Tripathi Shubham, Deem Michael W

Abstract excerpt

The standard genetic code is well known to be optimized for minimizing the phenotypic effects of single-nucleotide substitutions, a property that was likely selected for during the emergence of a universal code. Given the fitness advantage afforded by high standing genetic diversity in a population in a dynamic environment, it is possible that selection to explore a large fraction of the space of functional...

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PMID: 29959476
DOI: 10.1007/s00239-018-9852-x

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