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Article

Environmental changes bridge evolutionary valleys.

Science advances - 1 Jan 2016

Steinberg Barrett, Ostermeier Marc

Abstract excerpt

In the basic fitness landscape metaphor for molecular evolution, evolutionary pathways are presumed to follow uphill steps of increasing fitness. How evolution can cross fitness valleys is an open question. One possibility is that environmental changes alter the fitness landscape such that low-fitness sequences reside on a hill in alternate environments. We experimentally test this hypothesis on the antibiotic...

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Share to Anti-Bacterial Agents
Share to beta-Lactamases
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Environment

Share to Epistasis, Genetic

Share to Evolution, Molecular

Share to Genetic Fitness

Share to Selection, Genetic

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Identifiers

PMID: 26844293
DOI: 10.1126/sciadv.1500921
PMCID: PMC4737206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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