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Article

The Saccharomyces cerevisiae 14-3-3 proteins Bmh1 and Bmh2 directly influence the DNA damage-dependent functions of Rad53.

Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 2007

Usui Takehiko, Petrini John H J

Abstract excerpt

In this study, we mutated autophosphorylation sites in Rad53 based on their conservation with previously identified autophosphorylation sites in the mammalian Rad53 ortholog, Chk2. As with wild-type Rad53, the autophosphorylation mutant, rad53-TA, undergoes Mec1/Tel1-dependent interactions with Rad9 and Dun1 in response to genotoxic stress. Whereas rad53-TA in vitro kinase activity is severely impaired, the...

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Identifiers

PMID: 17299042
DOI: 10.1073/pnas.0611259104
PMCID: PMC1797148

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Source receipt: pubmed, retrieved 7 Sept 2026.

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