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Article

High-density SNP arrays improve detection of HER2 amplification and polyploidy in breast tumors.

BMC cancer - 6 Feb 2015

Hansen Thomas V O, Vikesaa Jonas, Buhl Sine S, Rossing Henrik H, Timmermans-Wielenga Vera, Nielsen Finn C

Abstract excerpt

BACKGROUND: Human epidermal growth factor receptor-2 (HER2) overexpression and gene amplification are currently established by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), respectively. This study investigates whether high-density single nucleotide polymorphism (SNP) arrays can provide additional diagnostic power to assess HER2 gene status. METHODS: DNA from 65 breast tumor samples...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25655188
DOI: 10.1186/s12885-015-1035-1
PMCID: PMC4326399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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