Genomewide scan for loss of heterozygosity and chromosomal amplification in breast carcinoma using single-nucleotide polymorphism arrays.

doi:10.1016/j.cancergencyto.2008.01.001

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Article

Genomewide scan for loss of heterozygosity and chromosomal amplification in breast carcinoma using single-nucleotide polymorphism arrays.

Cancer genetics and cytogenetics - 15 Apr 2008

Argos Maria, Kibriya Muhammad G, Jasmine Farzana, Olopade Olufunmilayo I, Su Tao, Hibshoosh Hanina, Ahsan Habibul

Abstract excerpt

In an effort to identify novel genes implicated in breast carcinogenesis, a genomewide scan for loss of heterozygosity (LOH) and copy number changes in paired-DNA samples extracted from normal and tumor tissue of frozen sections from women undergoing surgery for invasive breast cancer was conducted. The Affymetrix 10K SNP array was used to examine genomewide LOH of chromosomal regions. The number of LOH events,...

Topics

Breast Neoplasms
Case-Control Studies
Chromosome Aberrations
Chromosome Mapping
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 2
Female
Gene Amplification
Gene Dosage
Genome, Human

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Loss of Heterozygosity

Middle Aged

Oligonucleotide Array Sequence Analysis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 18406867
DOI: 10.1016/j.cancergencyto.2008.01.001
PMCID: PMC3972020

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