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Article

Deletion of chromosomes 13q and 14q is a common feature of tumors with BRCA2 mutations.

PloS one - 1 Jan 2012

Rouault Audrey, Banneau Guillaume, Macgrogan Gaëtan, Jones Natalie, Elarouci Nabila, Barouk-Simonet Emmanuelle, Venat Laurence, Coupier Isabelle, Letouzé Eric, de Reyniès Aurélien, Bonnet Françoise, Iggo Richard, Sévenet Nicolas, Longy Michel

Abstract excerpt

INTRODUCTION: Germline BRCA1 or BRCA2 mutations account for 20-30% of familial clustering of breast cancer. The main indication for BRCA2 screening is currently the family history but the yield of mutations identified in patients selected this way is low. METHODS: To develop more efficient approaches to screening we have compared the gene expression and genomic profiles of BRCA2-mutant breast tumors with those of...

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Share to Chromosome Deletion
Share to Chromosomes, Human, Pair 13

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Comparative Genomic Hybridization

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Source

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Identifiers

PMID: 23284877
DOI: 10.1371/journal.pone.0052079
PMCID: PMC3528765

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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