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Article

Integrated analysis of copy number and loss of heterozygosity in primary breast carcinomas using high-density SNP array.

International journal of oncology - 1 Sept 2011

Ching Ho Ching, Naidu Rakesh, Seong Mun Kein, Har Yip Cheng, Taib Nur Aishah Mohd

Abstract excerpt

Breast cancer is a heterogeneous disease, marked by extensive chromosomal aberrations. In this study, we aimed to explicate the underlying chromosomal copy number (CN) alterations and loss of heterozygosity (LOH) implicated in a cohort of Malaysian hospital-based primary breast carcinoma samples using a single nucleotide polymorphism (SNP) array platform. The analysis was conducted by hybridizing the extracted...

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PMID: 21687935
DOI: 10.3892/ijo.2011.1081

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