Article

Serum Metabolites and Parkinson‘s Disease: A Bidirectional Mendelian Randomization Study

2026-08-27

Abstract excerpt

<title>Abstract</title> <p>Purpose Parkinson’s disease (PD) is the second most common neurodegenerative disorder, yet its etiology remains incompletely understood. Methods Using a two-sample Mendelian randomization approach, we systematically evaluated the causal associations of 1,091 serum metabolites and 309 metabolite ratios with PD risk. Metabolite summary data were derived from a large-scale GWAS of 8,299...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: 8b860ed1-ac1b-59d2-9058-4d8d8dc6b932
DOI: 10.21203/rs.3.rs-10741350/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Serum Metabolites and Parkinson‘s Disease: A Bidirectional Mendelian Randomization StudyDOI 10.21203/rs.3.rs-10741350/v1Read

Cerebrospinal Fluid and Plasma Metabolites with Parkinson’s Disease: A Mendelian Randomization StudySemantic proximity Read

Cerebrospinal fluid and plasma metabolites in Parkinson's disease: a Mendelian randomization study.Semantic proximity Read

Exploring Potential Causal Links: How Parkinson’s Disease Brain Damage Impacts Liver Health–A Mendelian Randomization and Transcriptomic StudySemantic proximity Read

Mendelian randomization study of causal link from Cerebrospinal fluid metabolomics to neurodegenerative diseases.Semantic proximity Read

Causal effect of gut-microbiota-derived metabolite trimethylamine N-oxide on Parkinson's disease: A Mendelian randomization study.Semantic proximity Read

Assessing Causal Relationship Between Human Blood Metabolites and Five Neurodegenerative Diseases With GWAS Summary StatisticsSemantic proximity Read

Systematic genome-wide Mendelian randomization reveals the causal links between miRNAs and Parkinson’s diseaseSemantic proximity Read

Unveiling the causal effects of phosphatidylethanolamine (18:1_0:0) via glutamine conjugate of C6H10O2 (2) and X-23648 in Parkinson's disease: insights from mediation Mendelian randomization.Semantic proximity Read

Plasma lipidome, circulating inflammatory proteins, and Parkinson’s disease: a Mendelian randomization studySemantic proximity Read

Investigating the Genetic Association of 40 Biochemical Indicators with Parkinson's Disease.Semantic proximity Read

Exploring blood metabolites and thyroid disorders: a bidirectional mendelian randomization studySemantic proximity Read

Risk of Alzheimer's disease and genetically predicted levels of 1400 plasma metabolites: a Mendelian randomization study.Semantic proximity Read