Article
The effect of uridine diphosphate glucuronosyltransferase (UGT)1A6 genetic polymorphism on valproic acid pharmacokinetics in Indian patients with epilepsy: a pharmacogenetic approach.
Molecular diagnosis & therapy - 1 Oct 2013
Munisamy Murali, Tripathi Manjari, Behari Madhuri, Raghavan S, Jain D C, Ramanujam Barghavi, Arumugam Karthik, Rajakannan Thiyagu, Mallayasamy Surulivel Rajan, Subbiah Vivekanandhan
Abstract excerpt
BACKGROUND AND OBJECTIVE: Sodium valproate is a widely prescribed broad-spectrum antiepileptic drug. It shows high inter-individual variability in pharmacokinetics and pharmacodynamics and has a narrow therapeutic range. We evaluated the effects of polymorphic uridine diphosphate glucuronosyltransferase (UGT)1A6 (541A>G, 552A>C) metabolizing enzyme on the pharmacokinetics of sodium valproate in the patients with...
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