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Article

Neuronal activity regulates the nuclear proteome to promote activity-dependent transcription.

The Journal of cell biology - 6 Dec 2021

Herbst Wendy A, Deng Weixian, Wohlschlegel James A, Achiro Jennifer M, Martin Kelsey C

Abstract excerpt

The formation and plasticity of neuronal circuits relies on dynamic activity-dependent gene expression. Although recent work has revealed the identity of important transcriptional regulators and of genes that are transcribed and translated in response to activity, relatively little is known about the cell biological mechanisms by which activity alters the nuclear proteome of neurons to link neuronal stimulation...

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PMID: 34617965
DOI: 10.1083/jcb.202103087
PMCID: PMC8504181

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