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Article

The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility.

Neuron - 27 Jun 2018

Wall Mark J, Collins Dawn R, Chery Samantha L, Allen Zachary D, Pastuzyn Elissa D, George Arlene J, Nikolova Viktoriya D, Moy Sheryl S, Philpot Benjamin D, Shepherd Jason D, Müller Jürgen, Ehlers Michael D, Mabb Angela M, Corrêa Sonia A L

Abstract excerpt

Neuronal activity regulates the transcription and translation of the immediate-early gene Arc/Arg3.1, a key mediator of synaptic plasticity. Proteasome-dependent degradation of Arc tightly limits its temporal expression, yet the significance of this regulation remains unknown. We disrupted the temporal control of Arc degradation by creating an Arc knockin mouse (ArcKR) where the predominant Arc ubiquitination...

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Identifiers

PMID: 29861284
DOI: 10.1016/j.neuron.2018.05.012
PMCID: PMC6030446

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