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Article

Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Dec 2015

Dai Jinxiang, Bercury Kathryn K, Jin Weilin, Macklin Wendy B

Abstract excerpt

The oligodendrocyte transcription factor Olig1 is critical for both oligodendrocyte development and remyelination in mice. Nuclear to cytoplasmic translocation of Olig1 protein occurs during brain development and in multiple sclerosis, but the detailed molecular mechanism of this translocation remains elusive. Here, we report that Olig1 acetylation and deacetylation drive its active translocation between the...

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Source

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Identifiers

PMID: 26631469
DOI: 10.1523/JNEUROSCI.0882-15.2015
PMCID: PMC4666914

Genes

HDAC1
HDAC10
HDAC3
NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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