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Article

Identification of HDAC4 as a target of γ-catenin that regulates the oncogenic K-Ras-mediated malignant phenotype of Rat2 cells.

Biochemical and biophysical research communications - 5 Jul 2013

Yim Ji-Hye, Baek Jeong-Hwa, Lee Chang-Woo, Kim Min-Jung, Yun Hong Shik, Hong Eun-Hee, Lee Su-Jae, Park Jong Kuk, Um Hong-Duck, Hwang Sang-Gu

Abstract excerpt

The mechanisms by which activated Ras accelerates malignant transformation of normal cells are not fully understood. Here, we characterized the role and molecular mechanism of γ-catenin in regulating the malignant phenotype of Rat2 cells induced by codon 12-mutant K-Ras (K-Ras12V). Suppression of γ-catenin signaling by K-Ras12V was an early event and played a crucial role in promoting the acquisition of a highly...

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Identifiers

PMID: 23747726
DOI: 10.1016/j.bbrc.2013.05.122

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HDAC4

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