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Article

The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation.

Scientific reports - 1 Feb 2018

Kasai Nobuhiro, Kadeer Ailijiang, Kajita Mihoko, Saitoh Sayaka, Ishikawa Susumu, Maruyama Takeshi, Fujita Yasuyuki

Abstract excerpt

Recent studies have revealed that newly emerging RasV12-transformed cells are often apically extruded from the epithelial layer. During this cancer preventive process, cytoskeletal proteins plectin and Epithelial Protein Lost In Neoplasm (EPLIN) are accumulated in RasV12 cells that are surrounded by normal cells, which positively regulate the apical elimination of transformed cells. However, the downstream...

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Source

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Identifiers

PMID: 29391412
DOI: 10.1038/s41598-018-20146-1
PMCID: PMC5794774

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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