A Historic Perspective and Overview of H-Ras Structure, Oncogenicity, and Targeting.

Abstract excerpt

H-Ras is a unique isoform of the Ras GTPase family, one of the most prominently mutated oncogene families across the cancer landscape. Relative to other isoforms, though, mutations of H-Ras account for the smallest proportion of mutant Ras cancers. Yet, in recent years, there have been renewed efforts to study this isoform, especially as certain H-Ras-driven cancers, like those of the head and neck, have become...

Topics

• History, 20th Century
• History, 21st Century
• Humans
• Molecular Targeted Therapy
• Mutation
• Neoplasms
• Proto-Oncogene Proteins p21(ras)
• Signal Transduction