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LC–MS based assay to measure intracellular compound levels in Mycobacterium smegmatis: Linking compound levels to cellular potency

6 Jun 2013

Abstract excerpt

Dihydrofolate reductase (DHFR) plays a central role in maintaining cellular pool of tetrahydrofolic acid, a cofactor necessary for DNA, RNA and protein synthesis. The clinical validation of DHFR as antibacterial target was established by the success of trimethoprim (TMP). DHFR is also an attractive target for identifying anti-tuberculosis molecules however, due to observed weak cellular potency, no DHFR...

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PMID: 23747411
DOI: 10.1016/j.mimet.2013.05.010

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