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The emergence of resistance to the antiparasitic selamectin in Mycobacterium smegmatis is improbable and contingent on cell wall integrity.

Microbiology spectrum - 6 May 2025

Ezquerra-Aznárez José Manuel, Gašparovič Henrich, Chiner-Oms Álvaro, Lucía Ainhoa, Blázquez Jesús, Comas Iñaki, Korduláková Jana, Aínsa José A, Ramón-García Santiago

Abstract excerpt

Tuberculosis remains the deadliest infectious disease of the 21st century. New antimicrobials are needed to improve treatment outcomes and enable therapy shortening. Drug repurposing is an alternative to the traditional drug discovery process. The avermectins are a family of macrocyclic lactones with anthelmintic activity active against Mycobacterium tuberculosis. However, their mode of action in mycobacteria...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40197087
DOI: 10.1128/spectrum.02332-24
PMCID: PMC12054103

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