Article
A temporal proteome dynamics study reveals the molecular basis of induced phenotypic resistance in Mycobacterium smegmatis at sub-lethal rifampicin concentrations.
Scientific reports - 6 Mar 2017
Giddey Alexander D, de Kock Elise, Nakedi Kehilwe C, Garnett Shaun, Nel Andrew J M, Soares Nelson C, Blackburn Jonathan M
Abstract excerpt
In the last 40 years only one new antitubercular drug has been approved, whilst resistance to current drugs, including rifampicin, is spreading. Here, we used the model organism Mycobacterium smegmatis to study mechanisms of phenotypic mycobacterial resistance, employing quantitative mass spectrometry-based proteomics to investigate the temporal effects of sub-lethal concentrations of rifampicin on the...
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