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Emergence of resistance to the antiparasitic selamectin in <i>Mycobacterium smegmatis</i> is improbable and contingent on cell wall integrity

2024-09-05

Abstract excerpt

Tuberculosis remains the deadliest infectious disease of the 21 st century. New antimicrobials are needed to improve treatment outcomes and enable therapy shortening. Drug repurposing is an alternative to the traditional drug discovery process. The avermectins are a family of macrocyclic lactones with anthelmintic activity active against Mycobacterium tuberculosis . However, their mode of action in mycobacteria...

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Literature Corpus work
08b0bee9-551b-5f12-9084-417c29509572
DOI
10.1101/2024.09.05.611451
Open publication

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Emergence of resistance to the antiparasitic selamectin in <i>Mycobacterium smegmatis</i> is improbable and contingent on cell wall integrityDOI 10.1101/2024.09.05.611451
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