Article
Targeting dormant phenotype acquired mycobacteria using natural products by exploring its important targets: In vitro and in silico studies.
Frontiers in cellular and infection microbiology - 1 Jan 2023
Sharma Shweta, Chikhale Rupesh, Shinde Nivedita, Khan A M, Gupta Vivek Kumar
Abstract excerpt
The dormant phenotype of Mycobacterium tuberculosis that develops during infection poses a major challenge in disease treatment, since these bacilli show tolerance to front-line drugs. An in vitro hypoxia dormancy model was established, which produced phenotypically dormant Mycobacterium smegmatis after prolonged incubation under conditions of low oxygen, low pH, and nutrient limitation. Bacilli in this model...
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