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Article

Inhibition of repair of O6-methyldeoxyguanosine and enhanced mutagenesis in rat-liver epithelial cells.

Mutation research - 1 Jun 1990

Alvi N K, Foiles P G, Williams G M

Abstract excerpt

The pro-mutagenicity of chemically-induced methylation of DNA at the O6 position of deoxyguanosine was studied in cultured adult rat liver epithelial cells. To modify the level of O6-methyldeoxyguanosine (O6-medGuo) resulting from exposure to an alkylating agent, partial depletion of the O6-alkylguanine-DNA alkyltransferase (AGT) repair system was produced by pretreatment of ARL 18 cells with a non-toxic dose of...

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Source

Identifiers

PMID: 2374558
DOI: 10.1016/0027-5107(90)90059-d

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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