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Article

Inhibition of repair of O6-methyldeoxyguanosine and enhanced mutagenesis in rat-liver epithelial cells.

Mutation research - 1 Jun 1990

Alvi N K, Foiles P G, Williams G M

Abstract excerpt

The pro-mutagenicity of chemically-induced methylation of DNA at the O6 position of deoxyguanosine was studied in cultured adult rat liver epithelial cells. To modify the level of O6-methyldeoxyguanosine (O6-medGuo) resulting from exposure to an alkylating agent, partial depletion of the O6-alkylguanine-DNA alkyltransferase (AGT) repair system was produced by pretreatment of ARL 18 cells with a non-toxic dose of...

Topics

Alkyl and Aryl Transferases
Animals
Cells, Cultured
DNA
DNA Repair
Deoxyguanosine
Epithelial Cells
Epithelium
Kinetics
Liver
Male
Methylnitronitrosoguanidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Rats

Rats, Inbred F344

Transferases

Source

Identifiers

PMID: 2374558
DOI: 10.1016/0027-5107(90)90059-d

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2374558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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