Article
Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA.
Cancer research - 15 Jul 2003
Arai Tsuyoshi, Kelly Vincent P, Komoro Kimiyo, Minowa Osamu, Noda Tetsuo, Nishimura Susumu
Abstract excerpt
The Mmh/Ogg1 gene product maintains the integrity of the genome by removing the damaged base 8-hydroxyguanine (8-OH-G), one of the major DNA lesions generated by reactive oxygen species. Using Ogg1-deficient mice, we sought to establish if cells having high amounts of 8-OH-G have the ability to proliferate and whether the mutation frequency increases after proliferation in vivo. When KBrO(3), a known renal...
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