Article
Relationship between the functional exon 3 deleted growth hormone receptor polymorphism and symptomatic osteoarthritis in women.
Annals of the rheumatic diseases - 1 Feb 2014
Claessen K M J A, Kloppenburg M, Kroon H M, Bijsterbosch J, Pereira A M, Romijn J A, van der Straaten T, Nelissen R G H H, Hofman A, Uitterlinden A G, Duijnisveld B J, Lakenberg N, Beekman M, van Meurs J B, Slagboom P E, Biermasz N R, Meulenbelt I
Abstract excerpt
BACKGROUND: Several studies suggest a role of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in the pathophysiology of primary osteoarthritis (OA). A common polymorphism of the GH receptor (exon 3 deletion, d3-GHR) is associated with increased GH/IGF-1 activity. OBJECTIVE: To study associations between the d3-GHR polymorphism and symptomatic OA. METHODS: In the GARP (Genetics, osteoARthritis...
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