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Article

Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis.

Annals of the rheumatic diseases - 1 Oct 2015

Evans Daniel S, Cailotto Frederic, Parimi Neeta, Valdes Ana M, Castaño-Betancourt Martha C, Liu Youfang, Kaplan Robert C, Bidlingmaier Martin, Vasan Ramachandran S, Teumer Alexander, Tranah Gregory J, Nevitt Michael C, Cummings Steven R, Orwoll Eric S, Barrett-Connor Elizabeth, Renner Jordan B, Jordan Joanne M, Doherty Michael, Doherty Sally A, Uitterlinden Andre G, van Meurs Joyce B J, Spector Tim D, Lories Rik J, Lane Nancy E

Abstract excerpt

OBJECTIVES: To identify genetic associations with hip osteoarthritis (HOA), we performed a meta-analysis of genome-wide association studies (GWAS) of HOA. METHODS: The GWAS meta-analysis included approximately 2.5 million imputed HapMap single nucleotide polymorphisms (SNPs). HOA cases and controls defined radiographically and by total hip replacement were selected from the Osteoporotic Fractures in Men (MrOS)...

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Aged
Aged, 80 and over
Case-Control Studies
Chondrogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Insulin-Like Growth Factor Binding Protein 3

Osteoarthritis, Hip

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Identifiers

PMID: 24928840
DOI: 10.1136/annrheumdis-2013-205020
PMCID: PMC4449305

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IGFBP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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