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Article

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis.

Arthritis and rheumatism - 1 Aug 2010

Valdes Ana M, Spector Tim D, Tamm Agu, Kisand Kalle, Doherty Sally A, Dennison Elaine M, Mangino Massimo, Tamm Ann, Kerna Irina, Hart Deborah J, Wheeler Margaret, Cooper Cyrus, Lories Rik J, Arden Nigel K, Doherty Michael

Abstract excerpt

OBJECTIVE: Smad3 (or, MADH3) is a key intracellular messenger in the transforming growth factor beta signaling pathway. In mice, Smad3 deficiency accelerates growth plate chondrocyte maturation and leads to an osteoarthritis (OA)-like disease. We undertook this study to investigate the role of genetic variation in SMAD3 in the risk of large-joint OA in humans. METHODS: Ten tag single-nucleotide polymorphisms...

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Source

Identifiers

PMID: 20506137
DOI: 10.1002/art.27530

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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