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Article

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis.

European journal of endocrinology - 1 Jan 2021

Pelsma I C M, Claessen K M J A, Slagboom P E, van Heemst D, Pereira A M, Kroon H M, Ramos Y F M, Kloppenburg M, Biermasz N R, Meulenbelt I M

Abstract excerpt

INTRODUCTION: Pathologically high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in patients with acromegaly are associated with arthropathy. Several studies highlight the potential role of the GH/IGF-1 axis in primary osteoarthritis (OA). We aimed to disentangle the role of IGF-1 levels in primary OA pathogenesis. METHODS: Patients from the Genetics osteoARthritis and Progression (GARP)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33112260
DOI: 10.1530/EJE-20-0904

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