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Article

Growth hormone receptor isoforms and fracture risk in adult-onset growth hormone-deficient patients.

Clinical endocrinology - 1 Nov 2016

Mormando M, Chiloiro S, Bianchi A, Giampietro A, Angelini F, Tartaglione L, Nasto L, Milardi D, Formenti A M, Giustina A, De Marinis L

Abstract excerpt

INTRODUCTION: Growth hormone deficiency is considered the most important factor determining skeletal fragility in hypopituitary patients. Osteoblasts and chondrocytes express growth hormone (GH) receptor. Two GH receptor isoforms (GHRi) have been identified: they differ for the presence/absence of a protein fragment encoded by exon 3 of GHR gene. Consequently, three genotypes were identified: carriers of both the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27437620
DOI: 10.1111/cen.13161

Genes

GHR

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