Article
MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis.
Brain : a journal of neurology - 1 Jun 2013
Lill Christina M, Schjeide Brit-Maren M, Graetz Christine, Ban Maria, Alcina Antonio, Ortiz Miguel A, Pérez Jennifer, Damotte Vincent, Booth David, Lopez de Lapuente Aitzkoa, Broer Linda, Schilling Marcel, Akkad Denis A, Aktas Orhan, Alloza Iraide, Antigüedad Alfredo, Arroyo Rafa, Blaschke Paul, Buttmann Mathias, Chan Andrew, Compston Alastair, Cournu-Rebeix Isabelle, Dörner Thomas, Epplen Joerg T, Fernández Óscar, Gerdes Lisa-Ann, Guillot-Noël Léna, Hartung Hans-Peter, Hoffjan Sabine, Izquierdo Guillermo, Kemppinen Anu, Kroner Antje, Kubisch Christian, Kümpfel Tania, Li Shu-Chen, Lindenberger Ulman, Lohse Peter, Lubetzki Catherine, Luessi Felix, Malhotra Sunny, Mescheriakova Julia, Montalban Xavier, Papeix Caroline, Paredes Lidia F, Rieckmann Peter, Steinhagen-Thiessen Elisabeth, Winkelmann Alexander, Zettl Uwe K, Hintzen Rogier, Vandenbroeck Koen, Stewart Graeme, Fontaine Bertrand, Comabella Manuel, Urcelay Elena, Matesanz Fuencisla, Sawcer Stephen, Bertram Lars, Zipp Frauke
Abstract excerpt
A recent genome-wide association study reported five loci for which there was strong, but sub-genome-wide significant evidence for association with multiple sclerosis risk. The aim of this study was to evaluate the role of these potential risk loci in a large and independent data set of ≈ 20,000 subjects. We tested five single nucleotide polymorphisms rs228614 (MANBA), rs630923 (CXCR5), rs2744148 (SOX8), ...