Article
The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.
Genes and immunity - 1 Jul 2010
Alcina A, Vandenbroeck K, Otaegui D, Saiz A, Gonzalez J R, Fernandez O, Cavanillas M L, Cénit M C, Arroyo R, Alloza I, García-Barcina M, Antigüedad A, Leyva L, Izquierdo G, Lucas M, Fedetz M, Pinto-Medel M J, Olascoaga J, Blanco Y, Comabella M, Montalban X, Urcelay E, Matesanz F
Abstract excerpt
Genome-wide association studies (GWAS) have revealed that different diseases share susceptibility variants. Twelve single-nucleotide polymorphisms (SNPs) previously associated with different immune-mediated diseases in GWAS were genotyped in a Caucasian Spanish population of 2864 multiple sclerosis (MS) patients and 2930 controls. Three SNPs were found to be associated with MS: rs1678542 in KIF5A (P=0.001, odds...
Topics
- Adaptor Proteins, Signal Transducing
- Antigens, Differentiation, T-Lymphocyte
- Autoimmune Diseases
- Case-Control Studies
- Genetic Predisposition to Disease
- Genome-Wide Association Study