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Article

Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer.

BMC cancer - 5 Jun 2013

Sarasqueta Arantza Fariña, Forte Giusi, Corver Wim E, de Miranda Noel F, Ruano Dina, van Eijk Ronald, Oosting Jan, Tollenaar Rob A E M, van Wezel Tom, Morreau Hans

Abstract excerpt

BACKGROUND: p53 (encoded by TP53) is involved in DNA damage repair, cell cycle regulation, apoptosis, aging and cellular senescence. TP53 is mutated in around 50% of human cancers. Nevertheless, the consequences of p53 inactivation in colon cancer outcome remain unclear. Recently, a new role of p53 together with CSNK1A1 in colon cancer invasiveness has been described in mice. METHODS: By combining data on...

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Identifiers

PMID: 23739040
DOI: 10.1186/1471-2407-13-277
PMCID: PMC3682902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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