Article
A functional variant of IC53 correlates with the late onset of colorectal cancer.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2011
Chen Jingzhou, Shi Yi, Li Ziyu, Yu Hui, Han Yu, Wang Xiaojian, Sun Kai, Yang Tao, Lou Kejia, Song Yan, Zhang Yinhui, Zhen Yisong, Zhang Guiguo, Hu Ying, Ji Jiafu, Hui Rutai
Abstract excerpt
The IC53 gene was reported to be upregulated in the colon adenocarcinoma cell line SW480. Here, we show that the expression level of IC53 is positively correlated with the grade and depth of invasion in adenocarcinoma of the colon. Injection of IC53 stably transfected HCT-116 cells into athymic nude mice promoted tumor growth. Furthermore, overexpression of IC53 increased cell invasive growth, which could be...
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