Article
Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age.
Journal of surgical oncology - 1 Jan 2011
Onozato Wataru, Yamashita Keishi, Yamashita Kazuya, Kuba Tatsuru, Katoh Hiroshi, Nakamura Takatoshi, Sato Takeo, Ihara Atsushi, Okayasu Isao, Watanabe Masahiko
Abstract excerpt
PURPOSE: Genetic alterations that are closely associated with patient prognosis can be landmarks of definitive therapeutic targets as well as useful biomarkers in human cancer clinics. METHODS: Three hundred seventy-eight colorectal cancer (CRC) patients were examined for K-ras mutations by single-strand conformation polymorphism (SSCP), with a subsequent 144 young colon cancer (YCC) patients added to validate...
Topics
- Adult
- Age Factors
- Aged
- Analysis of Variance
- Biomarkers, Tumor
- Colonic Neoplasms
- Colorectal Neoplasms
- Female
- Follow-Up Studies
- Genes, ras
- Genetic Markers
- Humans
- Male
- Middle Aged