Association of p53 mutations with short survival in colorectal cancer.

doi:10.1016/s0016-5085(94)94217-x

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Article

Association of p53 mutations with short survival in colorectal cancer.

Gastroenterology - 1 Jan 1994

Hamelin R, Laurent-Puig P, Olschwang S, Jego N, Asselain B, Remvikos Y, Girodet J, Salmon R J, Thomas G

Abstract excerpt

BACKGROUND/AIMS: Mutations in p53, a tumor suppressor gene located on chromosome 17p, are the most frequent genetic alterations found in human cancers. Increased intracellular concentration of p53, which is frequently but not systematically related to p53 mutation, has been proposed to be associa...

Topics

Aged
Alleles
Base Sequence
Colorectal Neoplasms
Female
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Prognosis
Regression Analysis
Survival Analysis
Tumor Suppressor Protein p53

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