Article
Accurate prediction of a minimal region around a genetic association signal that contains the causal variant.
European journal of human genetics : EJHG - 1 Feb 2014
Bochdanovits Zoltán, Simón-Sánchez Javier, Jonker Marianne, Hoogendijk Witte J, van der Vaart Aad, Heutink Peter
Abstract excerpt
In recent years, genome-wide association studies have been very successful in identifying loci for complex traits. However, typically these findings involve noncoding and/or intergenic SNPs without a clear functional effect that do not directly point to a gene. Hence, the challenge is to identify the causal variant responsible for the association signal. Typically, the first step is to identify all genetic...
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