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Article

Interpretation of association signals and identification of causal variants from genome-wide association studies.

American journal of human genetics - 14 May 2010

Wang Kai, Dickson Samuel P, Stolle Catherine A, Krantz Ian D, Goldstein David B, Hakonarson Hakon

Abstract excerpt

GWAS have been successful in identifying disease susceptibility loci, but it remains a challenge to pinpoint the causal variants in subsequent fine-mapping studies. A conventional fine-mapping effort starts by sequencing dozens of randomly selected samples at susceptibility loci to discover candidate variants, which are then placed on custom arrays or used in imputation algorithms to find the causal variants. We...

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PMID: 20434130
DOI: 10.1016/j.ajhg.2010.04.003
PMCID: PMC2869011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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